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KMID : 0369820150450060555
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 6 p.555 ~ p.560
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Simultaneous analysis of ibuprofen and pamabrom by HPLC
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Jun Hye-Suk
Kang Jong-Seong
Park Jeong-Sook
Cho Cheong-Weon
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Abstract
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A selective and simple HPLC method was developed for ibuprofen (IBF) and pamabrom (PAMB) from in bulk and drug product using the same conditions, which was operated on a reverse phase (C18 column) with water (60 %) and acetonitrile (40 %.) solutions at a flow rate of 1.0 mL/min. IBF was detected at 2.6 min and PAMB at 8.0 min, respectively at 254 nm. The correlation coefficient (R2) for IBF was 0.9999 and that of PAMB was 0.9998 in 125?2000 and 63?100 μg/mL, respectively. Intraday precision showed less than 1.0 % RSD. This method was validated in an aspect of linearity, precision, accuracy, limit of detection and limit of quantitation. This method was suggested to analysis the fixed dose combination tablet of IBF and PAMB.
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KEYWORD
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Combination, Ibuprofen, Pamabrom, Validation, HPLC analysis
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